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Objective To observe the clinical effect of Shexiang Baoxin pill,a traditional Chinese medicine,combined with nicorandil on microvascular angina pectoris.Methods Seventy patients with microangiopathic angina diagnosed by coronary angiography admitted to the First Affiliated Hospital of Baotou Medical College from January 2014 to August 2016 were enrolled,and they were divided into a control group and an observation group according to conplete random number table method,35 patients in each group.Both groups were given routine treatment,in the observation group,additionally,nicorandil 5 mg 3 times a day and 2 Shexiang Baoxin pills (22.5 mg per tablet),3 times a day were orally applied,the therapeutic course in both groups being 6 weeks.Before and after treatment,the changes of number of episodes of angina pectoris per week,of the total number of ST-segment depression leads and the minimum voltage amplitude of ST-segment depression in the 12-lead resting electrocardiogram and adverse reaction were observed in the two groups.Results The frequency of angina pectoris after treatment was less than that before treatment,the total number of ST segment depression leads was lower and the minimum voltage amplitude of ST segment depression was decreased compared with those before treatment in the two groups,the degree of change in the observation group being more significant than those in the control goup [angina attack frequency (times):5.2 ± 0.5 vs.9.4 ± 1.6,ST segment depression lead total number:2.3-± 0.2 vs.4.6 ± 2.1,ST segment depression lowest voltage amplitude (my):0.10 ± 0.01 vs.0.31 ± 0.01,all P ＜ 0.05].The adverse effects incidence showed no statistical significant differences between control group and observation group [14.3％ (5/35) vs.22.8％ (8/35),P ＞ 0.05] Conclusions On the basis of conventional medication,Shexiang Baoxin pills combined with nicorandil has obvious therapeutic effect for treatment of microangiopathic angina pectoris.
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Objective Calcification and graft failure may occur in aortic valved homografting as a result of immune rejection. This study was designed to examine the effects of immunosuppression in reducing immune rejection response and preventing calcification in rat aortic valved homograft(AVH). Methods Animals were randomly assigned into 3 test groups and 1 control group. SD-Wistar rats in the test groups received AVH of cryopreservation (group A), received AVH of cryopreservation followed by CsA treatment (group B), and received AVH preconditioned with monoclonal antibody against dendritic cells (DcmAb) diluted in 1:5 and cryopreserved then were treated with DcmAb postoperatively (group C), respectively. Rats in the control group(group D) were Wistar→Wistar.Rat AVH with myocardial cuff were transplanted into the abdominal aorta of rats. The rats were sacrificed in batchs at 2, 4, 8, 12 and 16 weeks postoperatively. Blood samples were obzained for detecting the expression of TCR-αβ, CD28. The AVH specimens were obtained for observing the change of endotheliocyte and smooth muscle cells with light and electron microscopes. At the same time, calcium contents of AVH tissues after transplantation were measured. Results As compared with the control group, the expression of TCR-αβ and CD28 in test groups was increased significantly at each time point(P<0.01) and reached peaks 2 to 4 weeks after operation, then gradually reduced and was closed to the level of controls at 12 weeks. Calcium contents of AVH tissues in the test groups was increased gradually since 4 weeks and reached the peak 12 to 16 weeks after operation. No significant difference in calcium level was found in the control group over 5 different periods (P>0.05). Calcium contents of AVH tissues at 4 and 8 weeks postoperatively were (2856±79)μg/g and (3587±168)μg/g in the groups with cryopreservation;(2518±73)μg/g,(3237±187)μg/g in the CsA treatment group;(2176±210)μg/g, (3089±176)μg/g in the DCmAb treatment group; (860±60) μg/g, (870±50) μg/gin the control group. Conclusion The immunosuppressive treatment had substantial effects on AVH calcification as a result of reduction in immune rejection response and delay in the development of calcification.
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Objective To review and sum up the experience of diagnosis and surgical treatment of cardiac myxoma. Methods 133 patients with cardiac myxoma of different locations from January 1990 to May 2007 admitted in Qilu Hospital of Shandong University and Department of Cardivovascular Affdiafed Zhong shan Hospital of Xiamen Unversity were clearly diagnosed by two dimensional echecardiography. The tumors of 109 patients were located in left atrium ,22 in right atrium and 2 in both cardiac atria. All the patients underwent tumor extirpation under extracor-poreal circulation. Atrioventricular valve plasty was performed when necessary. 11 underwent bicuspid valvuloplasty and 6 underwent tricuspid valvuloplasty at the same time. All the minors were sent to histopathology examination. Re-suits Two patients died of low cardiac output syndrome in early postoperative period. Cerebral embolism happened in 6 cases,left lower extremity embolism and pulmonary embolism in 1 ease respectively. Other patients' symptoms were improved and the physical sign disappeared. All the tumors were demonstrated to be benign cardiac myxoma. Conclusions Most cardiac myxoma is benign but its clinical consequence is severe. So tumor extirpation should be performed as soon as possible and the following-up is important after operation. Prevention of tumor defluvium is im-portant. Two dimensional echocardiography is preferred in the diagnosis of cardiac myxoma.
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Objectives:To study the pathological behavior and the value of transforming growth factor β1(TGF-β1) in predicting prognosis in pulmonary hypertension associated with congenital heart disease. Methods:Lung tissues from 29 patients with congenital heart diseases associated with pulmonary hypertension were examined by surgical biopsy of the lung. All samples were examined for the expression and localization of TGF-β1 by immunohistochemical technique with anti-TGF-β1 antibody. Results:Twenty-six out of 29 showed positive staining of intracellular endotheliocyte TGF-β1(89.65%),16 samples showed extracellular matrix TGF-β1 staining(55.17%).Statistically, there was significant difference between Ⅰ～Ⅱ and Ⅲ～Ⅵ pathological degrees in extracellular matrix(P<0.05). Conclusions: TGF-β1 plays an important biological role in the formation of pulmonary hypertension after congenital heart disease. It is conductive in predicting prognosis.
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Objects To evaluate the immunosuppressive effect of marine preparation JLB extracted from Argopecten irradisus on aortic valve allograft durability. Methods The aortic valve homograft heterotopically allografted onto abdominal aorta from SD to Wistar rats. Then Wistar rats were divided into 2 groups. Test group was treated with JLB (0.5g?kg~ -1). The other group served as control. The rats were sacrificed in batches at 2, 4, 8and 12 weeks postoperatively. Blood samples and AVH were obtained for accessing the expression of CD25, CD71 and CD28. Results The expression of CD25, CD71 and CD28 in test group decreased more than that of control group at early stage of the transplantation. Conclusion JLB treatment can inhibit immune response at early stage after the transplantation.